For an oocyte to be Prepared for fertilization and growth into an embryo, the right set of genes needs to be turned on. Namekawa suspected that this pre-programming of the oocyte genome happens in various phases — the initial one starting throughout the time a feminine is born. He believed that chromatin remodeling proteins did Significantly of this function, by shifting spools around.
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Munakata and Namekawa will Assess mice with standard and mutated versions of the chromatin remodeler. Because the mice increase and mature, they're going to observe whether the existence or absence of the protein triggers distinctions inside the arrangement of DNA spools within the animals’ oocytes. And they'll watch whether this, consequently, alters the sample of gene expression after some time.
Each one has a mass of thread-like DNA — akin to 400 miles of yarn. To help keep it from devolving right into a tangle, the DNA is wrapped all around a series of protein spools, identified as nucleosomes.
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